advice on incremental backups to NFS storage

I’d like to get some advice and pointers from fellow users of percona xtradb and xtrabackup.

I am working on backing up a fairly busy database server(4.8TB) to an NFS export hosted on a NAS4Free server.
I am not allowed to take it offline during the backup.

Other than making sure to mount the NFS share with noac,noasync are there other things I should watch out for?
(from percona post:[URL=“http://www.mysqlperformanceblog.com/2010/12/09/using-xtrabackup-on-nfs-for-mysql-backups/”]http://www.mysqlperformanceblog.com/...mysql-backups/[/URL])

Also, should I use xtrabackup or innobackupex? Am I correct in my understanding that xtrabackup is used to backup
a database with purely innodb tables? In my case, the main database(4.5TB) is all innodb but the other databases like
mysql contain myisam tables. So in my case, I should use innobackupex to backup all databases?

Database server information:

lsb_release:Ubuntu 12.04.1 LTS

mysqld --version:
mysqld Ver 5.5.28-29.1-log for Linux on x86_64 (Percona Server (GPL), Release 29.1)

xtrabackup --version:
xtrabackup version 2.0.4 for Percona Server 5.1.59 unknown-linux-gnu (x86_64) (revision id: undefined)

innobackup --version:
InnoDB Backup Utility v1.5.1-xtrabackup

10 second load via dstat -cmndr:
----total-cpu-usage---- ------memory-usage----- -net/total- -dsk/total- --io/total-
usr sys idl wai hiq siq| used buff cach free| recv send| read writ| read writ
10 0 86 4 0 0|39.9G 143M 7104M 211M| 0 0 | 589k 8184k|36.2 893
16 1 75 7 0 0|39.9G 143M 7105M 211M| 997k 1628k|2912k 18M| 182 3089
17 1 76 6 0 0|39.9G 143M 7105M 211M| 975k 1634k|2128k 15M| 133 2809
22 1 66 10 0 0|39.9G 143M 7106M 209M|1382k 2308k| 960k 24M|60.0 1917
15 1 76 8 0 0|39.9G 143M 7106M 209M| 701k 1112k|2048k 15M| 128 1400
15 1 74 11 0 0|39.9G 143M 7106M 209M| 633k 1101k| 752k 22M|47.0 1604
18 1 72 8 0 1|39.9G 143M 7078M 237M|1504k 2875k| 848k 20M|53.0 1634
16 1 73 10 0 0|39.9G 143M 7079M 237M| 645k 1659k| 480k 21M|30.0 1194
14 0 67 18 0 0|39.9G 143M 7079M 237M| 599k 793k| 320k 15M|20.0 593