Not quite sure what to say but it looks like might be related to ProxySQL, I bet that if you’re trying to connect 7th App straight to one of the nodes it works.
(I haven’t used ProxySQL for a while to be fair) but are you sure you’re not hitting any ProxySQL limit like sessions or something similar?
What ProxySQL logs are saying?
Is that specific MySQL username tight to @‘some_ip_address/subnet’ that’s not allowed?