Hi mfedotov
Just to add to Peter 's point - we have reports of a successful deployment of PMM against 1,400 MySQL instances. So, yes, this is on the higher side, and adjustments may be needed in terms of METRICS_RESOLUTION, but given 16 cores you should be able to reach 500 per DC when running PMM 1.13 or later.
[url]Percona Monitoring and Management