Hi,
In the earlier version like 2.0 and 2.1, there were multiple binaries as per the mysql versions. i.e
nilnandan@desktop:~/Downloads/percona-xtrabackup-2.0.8/bin$ ll
total 118940
drwxr-xr-x 2 nilnandan nilnandan 4096 Sep 3 2013 ./
drwxr-xr-x 4 nilnandan nilnandan 4096 Sep 3 2013 …/
-rwxr-xr-x 1 nilnandan nilnandan 113912 Sep 3 2013 innobackupex*
lrwxrwxrwx 1 nilnandan nilnandan 12 Sep 3 2013 innobackupex-1.5.1 → innobackupex*
-rwxr-xr-x 1 nilnandan nilnandan 2258560 Sep 3 2013 xbstream*
-rwxr-xr-x 1 nilnandan nilnandan 12557890 Sep 3 2013 xtrabackup*
-rwxr-xr-x 1 nilnandan nilnandan 10667223 Sep 3 2013 xtrabackup_51*
-rwxr-xr-x 1 nilnandan nilnandan 15720860 Sep 3 2013 xtrabackup_55*
-rwxr-xr-x 1 nilnandan nilnandan 80404343 Sep 3 2013 xtrabackup_56*
nilnandan@desktop:~/Downloads/percona-xtrabackup-2.0.8/bin$
But from the 2.2 version, there are no separate binaries and as per the doc for single binary, “It can back up data from InnoDB, XtraDB, and MyISAM tables on MySQL 5.1 [other than builtin 5.1 InnoDB], 5.5 and 5.6 servers, as well as Percona Server with XtraDB.”
[url]Percona XtraBackup
So I don’t think it should create any issue. Still, I would suggest you to take backup, prepare and try to use it and let us know if you face any issue.