Hello @JoeMurray,
The only issue I can think of off the top of my head is that MariaDB uses a different style of GTID for replication, so if you are using GTID, that might be an issue. You can still use traditional binlog positioning to replicate between MariaDB → Percona. That would be the recommended upgrade path as well, setting up Percona Server instances as replicas for your current sources then doing a cut-over.
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